Mechanisms of ryanodine receptor 2 dysfunction in heart failure
نویسندگان
چکیده
منابع مشابه
Mechanisms of diastolic dysfunction in heart failure.
Abnormalities of diastole are common to most forms of congestive heart failure (HF). Diastolic function is broadly defined as the ability of the heart to fill adequately and at normal pressure to charge the ventricular pump for each subsequent contraction. It is determined by both active and passive processes occurring at the level of the myocyte, extracellular matrix, and left ventricular cham...
متن کاملRyanodine receptor dysfunction and triggered activity in the heart.
Arrhythmogenesis has been increasingly linked to cardiac ryanodine receptor (RyR) dysfunction. However, the mechanistic relationship between abnormal RyR function and arrhythmogenesis in the heart is not clear. We hypothesize that, under abnormal RyR conditions, triggered activity will be caused by spontaneous calcium release (SCR) events that depend on transmural heterogeneities of calcium han...
متن کاملDissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.
AIMS Calmodulin (CaM) is well known to modulate the channel function of the cardiac ryanodine receptor (RyR2). However, the possible role of CaM on the aberrant Ca(2+) release in diseased hearts remains unclear. In this study, we investigated the state of RyR2-bound CaM and channel dysfunctions in pacing-induced failing hearts. METHODS AND RESULTS The characteristics of CaM binding to RyR2 an...
متن کاملCellular mechanisms of contractile dysfunction in human heart failure.
Numerous cellular abnormalities of heart muscle are associated with ventricular dysfunction and the clinical syndrome of heart failure. Many of these changes have been described in animal models of heart failure where there is considerable species and model variation''. The increasing use of cardiac transplantation has provided access to fresh myocardial tissue from severely failing human heart...
متن کاملAltered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca Leak Through Ryanodine Receptor in Heart Failure
Background—In the pathogenesis of cardiac dysfunction in heart failure, a decrease in the activity of the sarcoplasmic reticulum (SR) Ca-ATPase is believed to be a major determinant. Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506–binding protein (FKBP12.6) with the cardiac ryanodine receptor (RyR) in a canine model of pacing-in...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2020
ISSN: 1759-5002,1759-5010
DOI: 10.1038/s41569-020-00443-x